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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
44.24
Human Site:
Y218
Identified Species:
69.52
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
Y218
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
Y218
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
Y218
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
Dog
Lupus familis
XP_852191
460
52810
Y202
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
Y218
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
Rat
Rattus norvegicus
Q91ZN7
476
54410
Y218
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
Y218
P
S
D
S
C
Q
E
Y
C
D
W
K
E
K
K
Chicken
Gallus gallus
Q8AYC9
476
53830
Y218
P
S
D
S
C
Q
E
Y
S
D
W
K
E
R
K
Frog
Xenopus laevis
Q6DE87
474
53957
E217
Q
P
N
E
V
C
Q
E
Y
C
D
W
K
E
K
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
Y169
P
S
E
N
C
Q
E
Y
L
D
W
L
E
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
F230
P
S
T
N
C
T
E
F
T
N
W
R
D
N
D
Honey Bee
Apis mellifera
XP_623436
467
53927
Y216
S
L
A
E
C
P
E
Y
M
A
W
R
D
G
K
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
Y238
A
S
D
A
S
Q
S
Y
M
G
W
I
S
N
T
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
Y218
P
T
Y
S
C
K
E
Y
C
D
W
L
D
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
Y179
T
A
C
G
T
P
N
Y
A
A
P
E
V
L
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
6.6
66.6
N.A.
33.3
33.3
33.3
60
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
33.3
86.6
N.A.
73.3
46.6
40
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
7
0
0
0
0
7
14
0
0
0
0
0
% A
% Cys:
0
0
7
0
80
7
0
0
14
7
0
0
0
0
0
% C
% Asp:
0
0
60
0
0
0
0
0
0
67
7
0
20
0
7
% D
% Glu:
0
0
7
14
0
0
80
7
0
0
0
7
60
7
0
% E
% Phe:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
7
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% I
% Lys:
0
0
0
0
0
7
0
0
0
0
0
54
7
54
80
% K
% Leu:
0
7
0
0
0
0
0
0
7
0
0
14
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
14
0
0
0
0
0
0
% M
% Asn:
0
0
7
14
0
0
7
0
0
7
0
0
0
14
7
% N
% Pro:
74
7
0
0
0
14
0
0
0
0
7
0
0
0
0
% P
% Gln:
7
0
0
0
0
67
7
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
14
0
14
0
% R
% Ser:
7
74
0
60
7
0
7
0
47
0
0
0
7
0
0
% S
% Thr:
7
7
7
0
7
7
0
0
7
0
0
0
0
0
7
% T
% Val:
0
0
0
0
7
0
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
87
7
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
87
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _